In Pfizer and Moderna's clinical trials for the BA.1 shots, participants who were already fully vaccinated with a booster shot received an updated booster dose.
Together, the evidence shows a potential roadmap for the side effects you can expect after getting one of the new boosters, and how severe those side effects might be. Those shots were never released to the public, because BA.1 was quickly surpassed by other omicron subvariants - but their design is extremely similar to the shots now available at pharmacies and clinics nationwide.
#Side effect of moderna booster trial#
They also examined clinical trial data on earlier versions of bivalent boosters targeting omicron's BA.1 subvariant. The federal agencies based their approvals off several other pieces of safety data, including evidence from the original Covid vaccines - the updated formulations are merely a tweak to those originals - and lab data on the shots' BA.5 element in mice. Side effect data isn't available yet because the new boosters were approved by the FDA and Centers for Disease Control and Prevention before fully completing their clinical trials. The reformulated shots from Pfizer and Moderna are bivalent, which means they target both the original Covid strain and omicron's BA.5 and BA.4 subvariants. Food and Drug Administration, tells CNBC Make It. Paul Offit, director of the Vaccine Education Center at Children's Hospital of Philadelphia and member of an independent advisory group to the U.S.
"We just don't have any data on this, essentially giving two vaccines in one shot - but biologically, I just wouldn't expect the side effects, severity or the safety profile of the shots to be different from the current mRNA vaccines and boosters," Dr.
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